It was revealed today, through the grape vine, that Bungie's next game, Destiny, will have cost so much at launch that Activision will need to sell as many as ten million copies to strike even. Ten million copies! That would make it one of the biggest launches of 2014, and it's a huge gamble to take. Few games manage to get more than ten million units, and Destiny is a new IP.
I don't know that I'd specifically call Destiny an MMO, but there are a lot of people that are. It's use of a persistant world, I suppose, is the biggest factor. If it manages to sell as many as it needs to strike even, it'll make it a game changer for the entire genre. If it doesn't, it still will influence everything else in the industry.